WebDec 2, 2010 · We speculate that CHSY1, which needs an intact Fringe domain to exert its NOTCH inhibitory activity, might post-translationally modify NOTCH-related proteins. However, substantiating that NOTCH … Webamount of CHSY1 in the co-culture conditioned medium, and this was associated with a 6.25-fold increase in apo-ptotic myeloma cells over control co-cultures. CHSY1 contains a Fringe domain, and Fringe is well known for its regulation of Notch signaling via its DDD motif. And interestingly, Fringe domain in CHSY1 has this DDD motif.
CHSY1 - Chondroitin sulfate synthase 1 - Function
WebNov 1, 2010 · CHSY1 was secreted from patient's fibroblasts where its absence triggered remarkable JAG1 synthesis and NOTCH up-regulation. Chsy1-knockdown in zebrafish embryos partially phenocopies the human disorder: increasing NOTCH output, impairing pectoral fin development and leading to dramatic retinal overgrowth. We conclude that … WebCHSY1. Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene. [5] [6] CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many ... biotechnology health management and care llc
Loss of CHSY1, a Secreted FRINGE Enzyme, Causes …
WebIntroduction. Gastric cancer is the malignant tumor with the highest morbidity and mortality among digestive system tumors. It is also the fourth most common malignant tumor in the world and the second leading cause of cancer-related death worldwide [Citation 1–3].At present, surgical treatment, drug chemotherapy, and radiotherapy are still the main … WebCHSY1. Chondroitin sulfate synthase 1 is an enzyme that in humans is encoded by the CHSY1 gene. [5] [6] CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan … WebSep 3, 2024 · Chondroitin synthase‑1 (CHSY1) is an enzyme responsible for the biosynthesis of chondroitin sulfate and has been implicated in the tumorigenesis of several cancer types; however, there is limited information regarding … daiwahouse montfoort