Hif1a breast cancer
Web8 de jul. de 2024 · Significance. We demonstrated that early B cell factor 1 (EBF1) is highly expressed in triple-negative breast cancer (TNBC) cells, and knockdown of EBF1 … Web8 de mar. de 2024 · d A positive correlation between HIF1A and PFKP levels in breast cancer was shown. Data based on METABRIC database. e Efficiencies of shRNAs against HIF1A in hypoxia (1% O 2, ...
Hif1a breast cancer
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Web9 de dez. de 2024 · HIF1A expression is elevated in brain metastases from breast cancer The transcription factor HIF1A is a canonical master-regulator of hypoxic signaling, … Web18 de ago. de 2024 · Background Breast cancer (BC) is the most common malignancy among women. Emerging studies have demonstrated that circular RNA (circRNA) zinc finger RNA binding protein (circZFR) serves as a crucial regulator in many human cancers. However, the role and mechanism of circZFR in BC tumorigenesis remain unclear. …
WebHIF1A. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.
Web1 de set. de 2010 · Surprisingly, activated HIF1a in cancer cells dramatically suppressed tumor growth, resulting in a 2-fold reduction in tumor mass and a 3-fold reduction … Web3 de ago. de 2024 · HIF1A can act a tumor suppressor by preventing expression of PPP1R1B and subsequent degradation of the p53 protein in pancreatic cancer cells, which reduces their invasive and metastatic activity. BACKGROUND & AIMS Pancreatic ductal adenocarcinomas (PDACs) are hypovascular, resulting in the upregulation of hypoxia …
Web4 de nov. de 2024 · Hypoxia-inducible factor-1α (HIF-1α) is a transcription factor that facilitates the adaptation of cancer cells to hypoxic conditions and may be prognostic of …
Web7 de jan. de 2012 · A hallmark of most solid tumors, hypoxic regions are associated with resistance to radiation and chemotherapy [1, 2].O 2 tension in advanced breast cancers can be as low as 0.1% to 1% O 2 [], a range commonly used to model tissue hypoxia in vitro.The oxygen-responsive hypoxia-inducible factor 1α (HIF-1α) protein, a master … how google uses cloud computingWebSignificant associations between HIF-1α overexpression and patient mortality have been shown in cancers of the brain (oligodendroglioma), breast, cervix, oropharynx, ovary … highest paid youtuber in indiaWebIn this study, we demonstrate that NRF2-silencing hindered HIF-1α accumulation in hypoxic breast cancer cells and subsequently suppressed hypoxia-inducible expression of … highest paid youtube nichesWeb17 de ago. de 2011 · Primary tumors facilitate metastasis by directing bone marrow-derived cells (BMDCs) to colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple members of the lysyl oxidase (LOX) family, … highest paid youtuber in the philippinesWeb27 de jun. de 2024 · To determine whether HIF1 transcriptionally regulates PAFAH1B2 expression in cancer cells, we used specific HIF1a siRNAs and plasmids to effectively reduce or enforce HIF1a expression. Knockdown ... Metabolic profiling reveals PAFAH1B3 as a critical driver of breast cancer pathogenicity. Chem. Biol., 21 (7) (2014), pp. 831 … highest paid youtuber in india per monthWebHypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong correlation between … highest paid youtubeWebExpression of HIF1A (bHLHe78, HIF-1alpha, HIF1, MOP1, PASD8) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... BREAST CANCER - Interactive survival scatter plot i & … highest paid youtube stars